Periodic Reporting for period 1 - TEDCIP (Targeting epigenetic demethylases: development of covalent inhibitors and PROTACs (Proteolysis Targeting Chimeras).)

One of the major epigenetic mechanisms involved in the dynamic regulation of gene expression is the reversible post-translational modification of histones. Among these post-translational modifications, methylation on histones play one of the most abundant types of...