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Periodic Reporting for period 4 - HYPER-INSIGHT (Hypermutated tumors: insight into genome maintenance and cancer vulnera...

Project: HYPER-INSIGHT

Updated at: 01-11-2024

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Project acronym HYPER-INSIGHT

Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules

Project: HYPER-INSIGHT

Updated at: 31-05-2024

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Project acronym HYPER-INSIGHT

Cell cycle gene alterations associate with a redistribution of mutation risk across chromosomal domains in human cancers

Project: HYPER-INSIGHT

Updated at: 31-05-2024

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Project acronym HYPER-INSIGHT

Proton and alpha radiation-induced mutational profiles in human cells

Project: HYPER-INSIGHT

Updated at: 31-05-2024

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Project acronym HYPER-INSIGHT

Prevalence, causes and impact of TP53-loss phenocopying events in human tumors

Project: HYPER-INSIGHT

Updated at: 31-05-2024

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Project acronym HYPER-INSIGHT

Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver events of human cancer

Project: HYPER-INSIGHT

Updated at: 31-05-2024

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Project acronym HYPER-INSIGHT

Variable efficiency of nonsense-mediated mRNA decay across human tissues, tumors and individuals

Project: HYPER-INSIGHT

Updated at: 31-05-2024

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Project acronym HYPER-INSIGHT

TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening

Project: HYPER-INSIGHT

Updated at: 27-04-2024

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Project acronym HYPER-INSIGHT

Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers.

Project: HYPER-INSIGHT

Updated at: 27-04-2024

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Project acronym HYPER-INSIGHT

Scales and mechanisms of somatic mutation rate variation across the human genome

Project: HYPER-INSIGHT

Updated at: 27-04-2024

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Project acronym HYPER-INSIGHT

Passenger mutations accurately classify human tumors

Project: HYPER-INSIGHT

Updated at: 27-04-2024

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Project acronym HYPER-INSIGHT

Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in...

Project: HYPER-INSIGHT

Updated at: 27-04-2024

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Project acronym HYPER-INSIGHT

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

Project: HYPER-INSIGHT

Updated at: 27-04-2024

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Project acronym HYPER-INSIGHT

The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes thr...

Project: HYPER-INSIGHT

Updated at: 27-04-2024

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Project acronym HYPER-INSIGHT

Mutational signatures are markers of drug sensitivity of cancer cells

Project: HYPER-INSIGHT

Updated at: 27-04-2024

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Project acronym HYPER-INSIGHT

To NMD or Not To NMD: Nonsense-Mediated mRNA Decay in Cancer and Other Genetic Diseases.

Project: HYPER-INSIGHT

Updated at: 27-04-2024

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Project acronym HYPER-INSIGHT

A framework for mutational signature analysis based on DNA shape parameters

Project: HYPER-INSIGHT

Updated at: 27-04-2024

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Project acronym HYPER-INSIGHT

The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy

Project: HYPER-INSIGHT

Updated at: 27-04-2024

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Project acronym HYPER-INSIGHT

Patterns of diverse gene functions in genomic neighborhoods predict gene function and phenotype

Project: HYPER-INSIGHT

Updated at: 27-04-2024

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Project acronym HYPER-INSIGHT

Whole genome DNA sequencing provides an atlas of somatic mutagenesis in healthy human cells and identifies a tumor-prone...

Project: HYPER-INSIGHT

Updated at: 27-04-2024

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Project acronym HYPER-INSIGHT

Spectrum of DNA mismatch repair failures viewed through the lens of cancer genomics and implications for therapy

Project: HYPER-INSIGHT

Updated at: 27-04-2024

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Project acronym HYPER-INSIGHT

The impact of rare germline variants on human somatic mutation processes

Project: HYPER-INSIGHT

Updated at: 27-04-2024

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Project acronym HYPER-INSIGHT

DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers

Project: HYPER-INSIGHT

Updated at: 27-04-2024

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Project acronym HYPER-INSIGHT

The evolutionary signal in metagenome phyletic profiles predicts many gene functions

Project: HYPER-INSIGHT

Updated at: 27-04-2024

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Project acronym HYPER-INSIGHT

Matching cell lines with cancer type and subtype of origin via mutational, epigenomic, and transcriptomic patterns

Project: HYPER-INSIGHT

Updated at: 27-04-2024

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Project acronym HYPER-INSIGHT

Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer ...

Project: HYPER-INSIGHT

Updated at: 27-04-2024

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Project acronym HYPER-INSIGHT

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Periodic Reporting for period 4 - HYPER-INSIGHT (Hypermutated tumors: insight into genome maintenance and cancer vulnera...

Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules

Cell cycle gene alterations associate with a redistribution of mutation risk across chromosomal domains in human cancers

Proton and alpha radiation-induced mutational profiles in human cells

Prevalence, causes and impact of TP53-loss phenocopying events in human tumors

Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver events of human cancer

Variable efficiency of nonsense-mediated mRNA decay across human tissues, tumors and individuals

TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening

Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers.

Scales and mechanisms of somatic mutation rate variation across the human genome

Passenger mutations accurately classify human tumors

Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in...

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes thr...

Mutational signatures are markers of drug sensitivity of cancer cells

To NMD or Not To NMD: Nonsense-Mediated mRNA Decay in Cancer and Other Genetic Diseases.

A framework for mutational signature analysis based on DNA shape parameters

The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy

Patterns of diverse gene functions in genomic neighborhoods predict gene function and phenotype

Whole genome DNA sequencing provides an atlas of somatic mutagenesis in healthy human cells and identifies a tumor-prone...

Spectrum of DNA mismatch repair failures viewed through the lens of cancer genomics and implications for therapy

The impact of rare germline variants on human somatic mutation processes

DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers

The evolutionary signal in metagenome phyletic profiles predicts many gene functions

Matching cell lines with cancer type and subtype of origin via mutational, epigenomic, and transcriptomic patterns

Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer ...