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TREM2 modulates differential deposition of modified and non‑modified Aβ species in extracellular plaques and intraneu...

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Differential interaction with TREM2 modulates microglial uptake of modified Aβ species

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC‐derived microglia

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer’s Disease

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Pathways linking Alzheimer’s disease risk genes expressed highly in microglia

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

A comprehensive roadmap for data and knowledge management for the PHAGO consortium, collection of pre-existing ethical d...

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Crystal structure of CD33 generated to ~3 Å and refined to ~2 Å

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Determination of the cleavage site

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Providing existing RNAseq signatures and cytokine/chemokine signatures of microglia from tg4510 (tau) mice at various ti...

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Knowledge of possible disease mechanisms and targets

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Knowledge of in vivo microglial activation in MCI/AD with respect to TREM2 genotype and in response to a systemic immune...

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Quantitative microglia Aß uptake measurement using methoxy-X04 administration, microglia isolation and FACS analysis, a...

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Longitudinal, individual two-photon in vivo analysis of microglial Aβ phagocytosis and degradation in the key AD-like m...

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Knowledge of phagocytosis and cytokine secretion in human iPSC derived microglia and macrophages linked to TREM2/DC33 mu...

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

TREM2 CLEAVAGE MODULATORS AND USES THEREOF

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

TREM2 CLEAVAGE MODULATORS AND USES THEREOF

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Characterise effect of CD33 expression and ligation on microglial phagocytosis, activation and neurotoxicity

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

TREM2 CLEAVAGE MODULATORS AND USES THEREOF

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Periodic Reporting for period 5 - PHAGO (Inflammation and AD: modulating microglia function focussing on TREM2 and CD33 ...

Project: PHAGO

Updated at: 18-04-2023

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Project acronym PHAGO

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

Project: PHAGO

Updated at: 07-03-2023

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Project acronym PHAGO

Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology

Project: PHAGO

Updated at: 07-03-2023

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Project acronym PHAGO

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TREM2 modulates differential deposition of modified and non‑modified Aβ species in extracellular plaques and intraneu...

Differential interaction with TREM2 modulates microglial uptake of modified Aβ species

A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC‐derived microglia

Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers

Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer’s Disease

Pathways linking Alzheimer’s disease risk genes expressed highly in microglia

A comprehensive roadmap for data and knowledge management for the PHAGO consortium, collection of pre-existing ethical d...

Crystal structure of CD33 generated to ~3 Å and refined to ~2 Å

Determination of the cleavage site

Providing existing RNAseq signatures and cytokine/chemokine signatures of microglia from tg4510 (tau) mice at various ti...

Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia

Knowledge of possible disease mechanisms and targets

Knowledge of in vivo microglial activation in MCI/AD with respect to TREM2 genotype and in response to a systemic immune...

Quantitative microglia Aß uptake measurement using methoxy-X04 administration, microglia isolation and FACS analysis, a...

Longitudinal, individual two-photon in vivo analysis of microglial Aβ phagocytosis and degradation in the key AD-like m...

Knowledge of phagocytosis and cytokine secretion in human iPSC derived microglia and macrophages linked to TREM2/DC33 mu...

TREM2 CLEAVAGE MODULATORS AND USES THEREOF

TREM2 CLEAVAGE MODULATORS AND USES THEREOF

Characterise effect of CD33 expression and ligation on microglial phagocytosis, activation and neurotoxicity

TREM2 CLEAVAGE MODULATORS AND USES THEREOF

Periodic Reporting for period 5 - PHAGO (Inflammation and AD: modulating microglia function focussing on TREM2 and CD33 ...

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology