ERD

Control of Innate Immunity by Sialic Acids in the Nervous Tissue

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Deletion of Alzheimer's disease‐associated CD33 results in an inflammatory human microglia phenotype

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Lipopolysaccharide activates microglia via neuraminidase 1 desialylation of Toll‐like Receptor 4

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Completion of the analysis of changes in the glycosylation of TREM2 ectodomains in the presence of R47H variants

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Final version of the roadmap for the data and knowledge management for the PHAGO consortium

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Analyze effect of anti-CD33 antibody in tg4510 and APP/PS1 transgenic mice

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Secretion studies of TREM2 and other shed proteins from iPSC- generated human microglia and macrophages

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Generating APP/PS1 mice with intracerebral Tau injections lacking TREM2, or harbouring human CD33 ki mutation, or lackin...

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Immunohistochemistry / Imaging analysis of key AD-like mouse lines harboring TREM2 or CD33 alterations

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Effect of CD33 ligands or desialylation on respiratory burst, lysosomal acidification, phagocytosis and cytokine release

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

UP-SCALED PRODUCTION OF MICROGLIA-LIKE/-PRECURSOR CELLS AND MACROPHAGE CELLS USING MESH MACROCARRIERS

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

TREM2 CLEAVAGE MODULATORS AND USES THEREOF

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease�...

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

The neuroinflammatory interleukin-12 signaling pathway drives Alzheimer's disease-like pathology by perturbing oligodend...

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate ina...

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Microglial phagocytosis of neurons in neurodegeneration, and its regulation

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Press release containing a common part and a part that can be personalised by every partner

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

CD33 receptor ligands characterization in human primary monocytes

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Launch of website, Twitter and other dissemination activities

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

CD33M inhibits microglial phagocytosis, migration and proliferation, but the Alzheimer’s disease‐protective variant ...

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

map the cleavage sites on TREM2 ectodomains in the presence/absence of the R47H variant

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Crystal structure of TREM2 generated to at least 2-3 Å Sanofi, AZ

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Final dissemination activity on project results

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

In vitro analysis of chimeric CD33 and the hCD33 ki mouse

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Identification of possible biomarkers

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Behavioural phenotyping before, at the beginning and after sustained Aβ deposition (3, 6 and 12 month of age of the key...

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Knowledge of TREM2/CD33 pathways of patient brain tissue and blood

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Resources

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Control of Innate Immunity by Sialic Acids in the Nervous Tissue

Deletion of Alzheimer's disease‐associated CD33 results in an inflammatory human microglia phenotype

Lipopolysaccharide activates microglia via neuraminidase 1 desialylation of Toll‐like Receptor 4

Completion of the analysis of changes in the glycosylation of TREM2 ectodomains in the presence of R47H variants

Final version of the roadmap for the data and knowledge management for the PHAGO consortium

Analyze effect of anti-CD33 antibody in tg4510 and APP/PS1 transgenic mice

Secretion studies of TREM2 and other shed proteins from iPSC- generated human microglia and macrophages

Generating APP/PS1 mice with intracerebral Tau injections lacking TREM2, or harbouring human CD33 ki mutation, or lackin...

Immunohistochemistry / Imaging analysis of key AD-like mouse lines harboring TREM2 or CD33 alterations

Effect of CD33 ligands or desialylation on respiratory burst, lysosomal acidification, phagocytosis and cytokine release

UP-SCALED PRODUCTION OF MICROGLIA-LIKE/-PRECURSOR CELLS AND MACROPHAGE CELLS USING MESH MACROCARRIERS

TREM2 CLEAVAGE MODULATORS AND USES THEREOF

A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease�...

Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

The neuroinflammatory interleukin-12 signaling pathway drives Alzheimer's disease-like pathology by perturbing oligodend...

Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate ina...

Microglial phagocytosis of neurons in neurodegeneration, and its regulation

Press release containing a common part and a part that can be personalised by every partner

CD33 receptor ligands characterization in human primary monocytes

Launch of website, Twitter and other dissemination activities

Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice

Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region

CD33M inhibits microglial phagocytosis, migration and proliferation, but the Alzheimer’s disease‐protective variant ...

map the cleavage sites on TREM2 ectodomains in the presence/absence of the R47H variant

Crystal structure of TREM2 generated to at least 2-3 Å Sanofi, AZ

Final dissemination activity on project results

In vitro analysis of chimeric CD33 and the hCD33 ki mouse

Identification of possible biomarkers

Behavioural phenotyping before, at the beginning and after sustained Aβ deposition (3, 6 and 12 month of age of the key...

Knowledge of TREM2/CD33 pathways of patient brain tissue and blood