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Activated microglia desialylate their surface, stimulating complement receptor 3‐mediated phagocytosis of neurons

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

The autophagy activator Spermidine ameliorates Alzheimer’s disease pathology and neuroinflammation in mice

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Does soluble TREM2 protect against Alzheimer’s Disease?

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Knowledge on cis interaction of CD33 receptor in human phagocytes and on the role of the exact sialic acid type (Neu5Ac ...

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Characterise phagocytosis, activation and neurotoxicity of microglia lacking TREM2 and/or expressing the R47H variant in...

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Knowledge of TREM2/CD33 pathways by RNA analyses/whole genome analyses in human microglial/macrophage populations

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Knowledge of TREM2/CD33 signalling (stress) pathways in human iPSC derived microglial/macrophages

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Knowledge of proteins in MCI/AD CSF with respect to TREM2 and CD33 genotypes

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Novel microglial genes associated with AD risk

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

TREM2 shedding by cleavage at the H157‐S158 bond is accelerated for the Alzheimer's disease‐associated H157Y variant

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disorder...

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Defici...

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or ...

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Loss of Function of TREM2 Results in Cytoskeletal Malfunction in Microglia

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

TREM2 triggers microglial density and age‐related neuronal loss

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

The endotoxin hypothesis of neurodegeneration

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

TREM2/CD33 RNA analyses of human microglial/macrophage populations

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Differential stimulation of pluripotent stem cell-derived human microglia leads to exosomal proteomic changes affecting ...

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Interleukin‐12/23 deficiency differentially affects pathology in male and female Alzheimer's disease‐like mice

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

Sialylation acts as a checkpoint for innate immune responses in the central nervous system

Project: PHAGO

Updated at: 29-04-2024

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Project acronym PHAGO

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Activated microglia desialylate their surface, stimulating complement receptor 3‐mediated phagocytosis of neurons

The autophagy activator Spermidine ameliorates Alzheimer’s disease pathology and neuroinflammation in mice

Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration

Does soluble TREM2 protect against Alzheimer’s Disease?

Knowledge on cis interaction of CD33 receptor in human phagocytes and on the role of the exact sialic acid type (Neu5Ac ...

Characterise phagocytosis, activation and neurotoxicity of microglia lacking TREM2 and/or expressing the R47H variant in...

Knowledge of TREM2/CD33 pathways by RNA analyses/whole genome analyses in human microglial/macrophage populations

Knowledge of TREM2/CD33 signalling (stress) pathways in human iPSC derived microglial/macrophages

Knowledge of proteins in MCI/AD CSF with respect to TREM2 and CD33 genotypes

Novel microglial genes associated with AD risk

TREM2 shedding by cleavage at the H157‐S158 bond is accelerated for the Alzheimer's disease‐associated H157Y variant

An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles

A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disorder...

Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain

Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Defici...

Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or ...

Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy

Small Molecule Binding to Alzheimer Risk Factor CD33 Promotes Aβ Phagocytosis

Loss of Function of TREM2 Results in Cytoskeletal Malfunction in Microglia

TREM2 triggers microglial density and age‐related neuronal loss

The endotoxin hypothesis of neurodegeneration

TREM2/CD33 RNA analyses of human microglial/macrophage populations

Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation

Differential stimulation of pluripotent stem cell-derived human microglia leads to exosomal proteomic changes affecting ...

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.

Interleukin‐12/23 deficiency differentially affects pathology in male and female Alzheimer's disease‐like mice

Sialylation acts as a checkpoint for innate immune responses in the central nervous system