ERD

Distribution of additionally approved CG sets and CP

Project: EUbOPEN

Updated at: 11-06-2024

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Project acronym EUbOPEN

Extended FRAGALYSIS cloud infrastructure for de novo compound design

Project: EUbOPEN

Updated at: 04-06-2024

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Project acronym EUbOPEN

Phosphorylation-linked complex profiling identifies assemblies required for Hippo signal integration

Project: EUbOPEN

Updated at: 01-06-2024

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Project acronym EUbOPEN

>1500 novel CG compounds sourced

Project: EUbOPEN

Updated at: 14-05-2024

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Project acronym EUbOPEN

A total of fifteen aggregated, anonymized and quality assured screening data sets released to the public

Project: EUbOPEN

Updated at: 14-05-2024

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Project acronym EUbOPEN

Acquisition of > 2,000 compounds for CGL covering >750 new targets

Project: EUbOPEN

Updated at: 14-05-2024

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Project acronym EUbOPEN

Revised target list

Project: EUbOPEN

Updated at: 14-05-2024

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Project acronym EUbOPEN

Standardized chip design and processing established

Project: EUbOPEN

Updated at: 14-05-2024

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Project acronym EUbOPEN

Evaluation of Raman assays and establishment of protocols in cell culture and patient-derived tissues

Project: EUbOPEN

Updated at: 14-05-2024

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Project acronym EUbOPEN

Additional ten PCAs established and/or optimised (20 in total)

Project: EUbOPEN

Updated at: 14-05-2024

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Project acronym EUbOPEN

The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods

Project: EUbOPEN

Updated at: 11-05-2024

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Project acronym EUbOPEN

Discovery of Conformationally Constrained ALK2 Inhibitors

Project: EUbOPEN

Updated at: 11-05-2024

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Project acronym EUbOPEN

Development of potent dual BET/HDAC inhibitors<i>via</i>pharmacophore merging and structure-guided optimization

Project: EUbOPEN

Updated at: 11-05-2024

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Project acronym EUbOPEN

Periodic Reporting for period 3 - EUbOPEN (EUbOPEN: Enabling and Unlocking biology in the OPEN)

Project: EUbOPEN

Updated at: 26-03-2024

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Project acronym EUbOPEN

Chemical Toolkit for PARK7: Potent, Selective, and High-Throughput

Project: EUbOPEN

Updated at: 28-12-2023

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Project acronym EUbOPEN

De novo design of immunoglobulin-like domains.

Project: EUbOPEN

Updated at: 28-12-2023

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Project acronym EUbOPEN

Discovery of Nanomolar DCAF1 Small Molecule Ligands.

Project: EUbOPEN

Updated at: 28-12-2023

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Project acronym EUbOPEN

Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21

Project: EUbOPEN

Updated at: 28-12-2023

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Project acronym EUbOPEN

PRMT inhibition induces a viral mimicry response in triple-negative breast cancer.

Project: EUbOPEN

Updated at: 28-12-2023

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Project acronym EUbOPEN

Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferas...

Project: EUbOPEN

Updated at: 28-12-2023

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Project acronym EUbOPEN

Technologies for Direct Detection of Covalent Protein–Drug Adducts

Project: EUbOPEN

Updated at: 28-12-2023

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Project acronym EUbOPEN

Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, ...

Project: EUbOPEN

Updated at: 07-12-2023

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Project acronym EUbOPEN

Cellular shape reinforces niche to stem cell signaling in the small intestine

Project: EUbOPEN

Updated at: 07-12-2023

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Project acronym EUbOPEN

Human resident liver myeloid cells protect against metabolic stress in obesity

Project: EUbOPEN

Updated at: 07-12-2023

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Project acronym EUbOPEN

Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformati...

Project: EUbOPEN

Updated at: 07-12-2023

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Project acronym EUbOPEN

CACHE (Critical Assessment of Computational Hit-finding Experiments): A public–private partnership benchmarking initia...

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortali...

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Structural basis of the TAM domain of BAZ2A in binding toDNA or RNA independent of methylation status

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

80 CRISPR knockout cell lines in years 2 and 3

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Histone H4K20 monomethylation enables recombinant nucleosome methylation by PRMT1 in vitro.

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Resources

Selected filters:

Distribution of additionally approved CG sets and CP

Extended FRAGALYSIS cloud infrastructure for de novo compound design

Phosphorylation-linked complex profiling identifies assemblies required for Hippo signal integration

>1500 novel CG compounds sourced

A total of fifteen aggregated, anonymized and quality assured screening data sets released to the public

Acquisition of > 2,000 compounds for CGL covering >750 new targets

Revised target list

Standardized chip design and processing established

Evaluation of Raman assays and establishment of protocols in cell culture and patient-derived tissues

Additional ten PCAs established and/or optimised (20 in total)

The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods

Discovery of Conformationally Constrained ALK2 Inhibitors

Development of potent dual BET/HDAC inhibitors<i>via</i>pharmacophore merging and structure-guided optimization

Periodic Reporting for period 3 - EUbOPEN (EUbOPEN: Enabling and Unlocking biology in the OPEN)

Chemical Toolkit for PARK7: Potent, Selective, and High-Throughput

De novo design of immunoglobulin-like domains.

Discovery of Nanomolar DCAF1 Small Molecule Ligands.

Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21

PRMT inhibition induces a viral mimicry response in triple-negative breast cancer.

Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferas...

Technologies for Direct Detection of Covalent Protein–Drug Adducts

Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, ...

Cellular shape reinforces niche to stem cell signaling in the small intestine

Human resident liver myeloid cells protect against metabolic stress in obesity

Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformati...

CACHE (Critical Assessment of Computational Hit-finding Experiments): A public–private partnership benchmarking initia...

JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortali...

Structural basis of the TAM domain of BAZ2A in binding toDNA or RNA independent of methylation status

80 CRISPR knockout cell lines in years 2 and 3

Histone H4K20 monomethylation enables recombinant nucleosome methylation by PRMT1 in vitro.