ERD

Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

3D human liver spheroids for translational pharmacology and toxicology

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Population pharmacogenomics: an update on ethnogeographic differences and opportunities for precision public health

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Nucelotide Binding, Evolutionary Insights and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

ALK2 Receptor Kinase Association with FKBP12.6 Is Structurally Conserved with the ALK2-FKBP12 Complex

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Phosphorylation of the DNA repair scaffold SLX4drives folding of the SAP domain and activation of theMUS81-EME1 endonucl...

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Initial protocols made openly available through portal and public databases

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Partnerships with >25 international partners

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Organotypic human ex vivo models for coronavirus disease 2019 research and drug development

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

PharmVar GeneFocus: CYP2B6

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Oral bioavailable and Blood Brain Barrier Penetrant PROTAC...

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

The Chemical Probes Portal: an expert review-based public resource to empower chemical probe assessment, selection and u...

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Dissecting the stability determinants of a challenging de novo protein fold using massively parallel design and experime...

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei.

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

The genetic landscape of major drug metabolizing cytochrome P450 genes—an updated analysis of population-scale sequenc...

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

The Small-Molecule Inhibitor MRIA9 Reveals Novel Insights into the Cell Cycle Roles of SIK2 in Ovarian Cancer Cells

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

New protein family sentinel selectivity panel

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Reprogramming Transcription Factors Oct4 and Sox2 Induce a BRD-Dependent Immunosuppressive Transcriptome in GBM-Propagat...

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade.

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Trends in kinase drug discovery: targets, indications and inhibitor design.

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Assembly of expanded reaction toolkit and fragment set for plate-based chemistry

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

RAS and PP2A activities converge on epigenetic gene regulation.

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Establish data publication standard and database

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Resources

Selected filters:

Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class

3D human liver spheroids for translational pharmacology and toxicology

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Population pharmacogenomics: an update on ethnogeographic differences and opportunities for precision public health

Nucelotide Binding, Evolutionary Insights and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4

Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells

ALK2 Receptor Kinase Association with FKBP12.6 Is Structurally Conserved with the ALK2-FKBP12 Complex

Phosphorylation of the DNA repair scaffold SLX4drives folding of the SAP domain and activation of theMUS81-EME1 endonucl...

Initial protocols made openly available through portal and public databases

Partnerships with >25 international partners

Organotypic human ex vivo models for coronavirus disease 2019 research and drug development

PharmVar GeneFocus: CYP2B6

Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders

Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Oral bioavailable and Blood Brain Barrier Penetrant PROTAC...

The Chemical Probes Portal: an expert review-based public resource to empower chemical probe assessment, selection and u...

Dissecting the stability determinants of a challenging de novo protein fold using massively parallel design and experime...

Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei.

The genetic landscape of major drug metabolizing cytochrome P450 genes—an updated analysis of population-scale sequenc...

The Small-Molecule Inhibitor MRIA9 Reveals Novel Insights into the Cell Cycle Roles of SIK2 in Ovarian Cancer Cells

New protein family sentinel selectivity panel

Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK

Reprogramming Transcription Factors Oct4 and Sox2 Induce a BRD-Dependent Immunosuppressive Transcriptome in GBM-Propagat...

3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis

PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade.

Trends in kinase drug discovery: targets, indications and inhibitor design.

Assembly of expanded reaction toolkit and fragment set for plate-based chemistry

A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins

RAS and PP2A activities converge on epigenetic gene regulation.

LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains

Establish data publication standard and database