ERD

Scaffold hopping from amodiaquine to novel Nurr1 agonist chemotypes via microscale analogue libraries.

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Structure and Function of Protein Arginine Methyltransferase PRMT7.

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Define criteria for compounds of CGL

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Data for initial CG set released

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Extended FRAGALYSIS cloud infrastructure for in silico compound design

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Autoantibodies against Four-and-a-Half-LIM Domain 1 (FHL1) in Inflammatory Myopathies: Results from an Australian Single...

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Genotoxicity and Epigenotoxicity of Carbazole-Derived Molecules on MCF-7 Breast Cancer Cells

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

EUbOPEN website implementation

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

SS148 and WZ16 inhibit the activities of nsp10-nsp16 complexes from all seven human pathogenic coronaviruses.

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Deposit intermediate set of data in sustainable resources

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

40 CRISPR knockout cell lines in year 1

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Se...

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

First set of community engagement events or symposium held

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Fam...

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Post-transcriptional and Post-translational Modifications of Primary Cilia: How to Fine Tune Your Neuronal Antenna.

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Family wide screening platform for kinases using NanoBRET or ABPP technology

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

The ethnogeographic variability of genetic factors underlying G6PD deficiency

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

High-content live-cell multiplex screen for chemogenomic compound annotation based on nuclear morphology

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

No shortcuts to SARS-CoV-2 antivirals.

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation.

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Ubiquitin ligases: guardians of mammalian development

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe.

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Online compound ordering system for the public

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Breaking free from the crystal lattice: Structural biology in solution to study protein degraders

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Resources

Selected filters:

Scaffold hopping from amodiaquine to novel Nurr1 agonist chemotypes via microscale analogue libraries.

Structure and Function of Protein Arginine Methyltransferase PRMT7.

Define criteria for compounds of CGL

Data for initial CG set released

Extended FRAGALYSIS cloud infrastructure for in silico compound design

Autoantibodies against Four-and-a-Half-LIM Domain 1 (FHL1) in Inflammatory Myopathies: Results from an Australian Single...

Genotoxicity and Epigenotoxicity of Carbazole-Derived Molecules on MCF-7 Breast Cancer Cells

EUbOPEN website implementation

SS148 and WZ16 inhibit the activities of nsp10-nsp16 complexes from all seven human pathogenic coronaviruses.

Deposit intermediate set of data in sustainable resources

The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification

40 CRISPR knockout cell lines in year 1

DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Se...

First set of community engagement events or symposium held

Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Fam...

Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance

Post-transcriptional and Post-translational Modifications of Primary Cilia: How to Fine Tune Your Neuronal Antenna.

Family wide screening platform for kinases using NanoBRET or ABPP technology

The ethnogeographic variability of genetic factors underlying G6PD deficiency

Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier

High-content live-cell multiplex screen for chemogenomic compound annotation based on nuclear morphology

No shortcuts to SARS-CoV-2 antivirals.

Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2

Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation.

Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity

Ubiquitin ligases: guardians of mammalian development

Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe.

Online compound ordering system for the public

Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes

Breaking free from the crystal lattice: Structural biology in solution to study protein degraders