ERD

Current Advances in CETSA

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase.

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Arginine ADP-Ribosylation: Chemical Synthesis of Post-Translationally Modified Ubiquitin Proteins

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Update on web-based internal database system development

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

First EUbOPEN website review and development

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Single tracer-based protocol for broad-spectrum kinase profiling in live cells with NanoBRET

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

In vitro and ex vivo modeling of enteric bacterial infections

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Additional five aggregated, anonymized and quality assured screening data sets released to the public

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Amide-to-ester substitution as a strategy for optimizing PROTAC permeability and cellular activity

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

A Concerted Action of UBA5 C-Terminal Unstructured Regions Is Important for Transfer of Activated UFM1 to UFC1

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase.

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Cdyl Deficiency Brakes Neuronal Excitability and Nociception through Promoting Kcnb1 Transcription in Peripheral Sensory...

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors.

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

A Chemical Toolbox for Labeling and Degrading Engineered Cas Proteins

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

20 CP in year 1

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Define target list of 1,000 targets

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

First version of platform for automated compound synthesis

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Insulin‐dependent glucose consumption dynamics in 3D primary human liver cultures measured by a sensitive and specific...

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Selective BH3 mimetics synergize with BET inhibition to induce mitochondrial apoptosis in rhabdomyosarcoma cells

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

A Screening of Epigenetic Therapeutic Targets for Non-Small Cell Lung Cancer Reveals PADI4 and KDM6B as Promising Candid...

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Detection of antibodies against the huntingtin protein in human plasma.

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

The human pseudouridine synthase PUS7 recognizes RNA with an extended multi-domain binding surface.

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Assembly and Application of a Low Budget Photoreactor**

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

100 protein structures in year 1

Project: EUbOPEN

Updated at: 30-10-2023

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Project acronym EUbOPEN

Resources

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Current Advances in CETSA

Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants

Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase.

A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.

Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy

Arginine ADP-Ribosylation: Chemical Synthesis of Post-Translationally Modified Ubiquitin Proteins

Update on web-based internal database system development

First EUbOPEN website review and development

Single tracer-based protocol for broad-spectrum kinase profiling in live cells with NanoBRET

In vitro and ex vivo modeling of enteric bacterial infections

Additional five aggregated, anonymized and quality assured screening data sets released to the public

Amide-to-ester substitution as a strategy for optimizing PROTAC permeability and cellular activity

A Concerted Action of UBA5 C-Terminal Unstructured Regions Is Important for Transfer of Activated UFM1 to UFC1

The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase.

Cdyl Deficiency Brakes Neuronal Excitability and Nociception through Promoting Kcnb1 Transcription in Peripheral Sensory...

Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments

The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors.

Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine

A Chemical Toolbox for Labeling and Degrading Engineered Cas Proteins

20 CP in year 1

Define target list of 1,000 targets

First version of platform for automated compound synthesis

Insulin‐dependent glucose consumption dynamics in 3D primary human liver cultures measured by a sensitive and specific...

Selective BH3 mimetics synergize with BET inhibition to induce mitochondrial apoptosis in rhabdomyosarcoma cells

A Screening of Epigenetic Therapeutic Targets for Non-Small Cell Lung Cancer Reveals PADI4 and KDM6B as Promising Candid...

Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism

Detection of antibodies against the huntingtin protein in human plasma.

The human pseudouridine synthase PUS7 recognizes RNA with an extended multi-domain binding surface.

Assembly and Application of a Low Budget Photoreactor**

100 protein structures in year 1